The objective of the present research is using Unmanned Aerial Vehicle System (UAVS) to probe the spatial and time variations of the pollutants in the air and water realm. In the air portion is to evaluate the performance of O3, NO2 and NMHC measurements using UAVs in Kaohsiung city. In the water portion, the pollutants discharged from factory waster water will be discussed. In this paper, a high-performance, long-endurance UAV system is developed to provide a platform for three-dimensional pollution measurement and monitoring requirements. The system includes carbon fiber composite airframe, GPS navigation, autopilot, RF data transmission and integrated air pollution sensing systems. The efficiency of each system are optimized and verified through numerical simulation or experiments, and interfaces between UAV and air pollution sensing systems are also considered to provide ideal air flow to the sensor under the extreme conditions at high altitude and high speed. Therefore, the UAV system can display air pollution measurement changes in real time and combine these results with GPS and geography data to monitor air quality in three dimension space. The air sensing results are compared with data from ground monitoring site. The result shows that the UAV system can offer real-time, 3-dimensional, and large area measuring results, which can obtain useful data for the government, industry, and research units. Also, when the water in our rivers, lakes, and oceans becomes polluted, the effects will be far reaching. It can endanger wildlife, make our drinking water unsafe. No doubt we need a more reliable tool to monitor the polluting water. Therefore a platform composed of the technologies of : Wing-In-Ground craft, the water-detecting sensors, the IT skill, and the cloud-computing service were bundled for this purpose . This platform can execute smart 3D UAV-based detecting technology of water pollution, and would be useful to make the coastal and river basin management more efficient.