This investigation uses feature matching which includes feature extraction, region descriptor and similarity assessment to initialize the correspondence for image registration. Shapes of the extracted regions appear to be in high frequency and low frequency in terms of shape irregularity. This irregularity, in general, is not predictable in the feature extraction stage Thus, we consider both possibility and then strive to investigate the suitable matching strategy. We propose three descriptors to characterize the region shapes, namely invariant moments, Fourier descriptors, and shape matrix. According to the matching matrix designed in this study, we screen out the erroneous correspondence. Then for these determined conjugate regions, centroids are used as registration control point in the initial stage. Following a coordinate transformation as prediction, fine matching is applied to generate final registration control point pairs.